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Casein and Whey: Understanding How Calves Digest Milk Proteins

Calf drinking milk from a bottleWhen we think about feeding calves, we often focus on the obvious—how much milk replacer to mix, feeding temperature, or whether to acidify or not. But beneath those daily routines lies a complex digestive process that determines how nutrients are released, digested, and absorbed.

Understanding how casein and whey proteins behave once they reach the abomasum (the calf’s stomach) helps you make smarter feeding decisions that support calf growth, digestion, and overall health.

A Tale of Two Proteins

Milk protein is made up of two key types: casein and whey. About 80% of the protein in whole milk is casein, while the remaining 20% is whey. These two act very differently inside the calf’s stomach.

  • Casein exists as small spherical structures called micelles, stabilized by κ-casein. When milk enters the abomasum, stomach acid (hydrochloric acid) and the enzyme pepsin break down these micelles, causing the casein to coagulate or form curds.
  • Whey proteins remain soluble in acid and do not clot. Instead, they take on a yogurt-like texture and flow freely with the liquid portion of the stomach contents, emptying quickly into the small intestine.

Why Clotting Matters for Calf Digestion

When casein curds form, they release nutrients slowly over several hours. This sustained digestion supports steady amino acid absorption, maintains stable blood nutrient levels, and can improve feed efficiency.

Whey proteins, on the other hand, move rapidly through the abomasum—offering quick energy but sometimes less efficient nutrient use if digestion happens too fast.

In nature, whole milk provides the perfect combination: a steady trickle of nutrients from casein and quick amino acids from whey—supporting gut health and optimal calf growth.

Milk Replacer Formulation and Clotting Behavior

Not all milk replacers act the same way. The protein source—casein or whey—determines how the milk behaves in the calf’s stomach.

  • Casein-based milk replacers form curds similar to whole milk and are ideal for very young calves (0–4 weeks old).
  • Whey-based milk replacers empty faster and allow quicker nutrient absorption but may not suit very young calves if enzyme capacity is still developing.

Many modern replacers use a blend of casein and whey to balance digestion and cost.

At Esmilco, we understand that every calf and operation is different. That’s why we specialize in custom-built milk replacers designed to deliver the right casein-to-whey balance for your feeding goals.

Key Takeaways

  • Casein proteins clot and digest slowly, supporting sustained nutrition.
  • Whey proteins digest quickly, providing fast energy.
  • The ideal casein-to-whey ratio helps maximize growth and digestive health.

Give Your Calves the Best Start

Healthy calves begin with the right nutrition plan.

Contact your Esmilco representative today to discuss how our custom milk replacers can improve calf digestion, feed efficiency, and overall performance.

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